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Generic AygestinNorethindrone 5mgWomen's Health |
| Package | Per Pill | Price | Order |
|---|---|---|---|
| 5mg × 30 pills | $0.99 | $29.74 | Buy |
| 5mg × 60 pills | $0.94 | $56.20 | Buy |
| 5mg × 90 pills | $0.81 | $72.74 | Buy |
| 5mg × 120 pills | $0.74 | $89.28 | Buy |
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Aygestin
Generic name: Norethindrone
Description: Norethindrone is a synthetic oral progestin. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. As an oral contraceptive, norethindrone is available as either a single agent or in combination with an estrogen. Progestin-only formulations or "mini-pills" of norethindrone are not widely used because of increased incidence of certain side effects such as irregular, unpredictable spotting and breakthrough bleeding. Progestin-only contraceptives have a higher risk of failure compared to estrogen-progestin combinations because of variable suppression of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in low-dose progestin-only regimens. Norethindrone was approved by the FDA in 1961. An implant dosage form for contraception is under investigation.
Mechanism of Action: The primary contraceptive effect of progestins involves the suppression of the midcycle surge of LH. The exact mechanism of action, however, is unknown. At the cellular level, progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge, thereby preventing follicular maturation and ovulation. Overall, progestin-only contraceptives prevent ovulation in 70.80% of cycles, however, the clinical effectiveness ranges 96.98%. This suggests that additional mechanisms may be involved. Other actions of norethindrone include alterations in the endometrium that can impair implantation and an increase in cervical mucus viscosity which inhibits sperm migration into the uterus. The administration of norethindrone to women with adequate estrogen production transforms the uterus from a proliferative to a secretory phase. Norethindrone has minimal estrogenic, androgenic, and anabolic activity.
Pharmacokinetics: Norethindrone is administered orally. Pharmacokinetic parameters for norethindrone are poorly understood. Norethindrone is moderately bound to plasma proteins. It is hepatically metabolized and eliminated in both the urine and the feces. The elimination half-life of norethindrone is about 10 hours.
Erectile Dysfunction (ED) is a term, normally used to identify various erection disorders or abnormalities in the functioning of penis blood circulation. Characterized by an insufficient hardness and stiffness of the penis or being unable to maintain the hardness, there are numerous physical and psychological factors that influence men’s sexual life. Psychological irritants can include an excessive attention or focus on the failure expectation but not on making love. Physical reasons can be referred to age, anomalies in the vessels of people with heart and vascular diseases, prostate surgery and smoking, drugs and alcohol dependence.
Muscle Relaxants do not form a class of drugs but rather a group of medications that has a specific and different central sedative effect on body muscles. Actually, they do not influence muscles directly, they act in the brain. The main prescription and application of these medications are to treat low back pain, related to muscle spasms. The pain, associated with the back, is described by tightness and tension in the muscles. The significance of treatment is recognized be many professional physicians as, leaving untreated, muscle spasms turn into muscle knots. These knots are more painful than spasms as they are excessive connective tissues that sometimes need to be extracted with the application of surgery.